Anyone had problems with 64 bit OS?

After reading Wikipedia article on 64-bit processing, I found some disadvantages of a 64 bit OS compared to 32 bit OS’s.
[LIST=1]
[]Data takes up a little more RAM due to swollen pointers and possibly other types and alignment padding.
[
]64 bit versions of device drivers must be available. You cannot run 32 bit drivers in emulation mode on a 64 bit OS.
[*]Some early 64 bit Intel processors had poor 32 bit emulation.
[/LIST]
So has anyone had the above problems or are these facts antiquated? With current technology, have all these problems been fixed? I’m considering moving up to 64 bit processing.