Interactive video with hotspots, but video can scale?!

Hi guys, so basically i got this video i need to make interactive, where the user will be able to click on hotspots in a video as it scales – any possible ideas or directions?

The idea i got is if i know my hotspot is initially at x:700 y:300, and the video scales, i just move it over by that much of a factor – from what my current resolution was to my new resolution?