Lightbox and divs

hi i have a question… i have made my portfolio like this when you click a link you reload only the content div but when i put lightbox on the page it shows the thubnails but it wont do its normal thing ( make the picture to real size and shows it on your screen ) it just goes to a new page and shows it like google images(when u search on google images for some image and selects 1 ) is is possible that you can make lightbox work when your pics are loaded in a div?