Listeners not working when published?

Anyone seen this? I have a project that when tested in Flash works perfect. But if I just run the .swf from my machine, or publish to an .exe various listeners do not seem to be working - specifically the MouseEvent.CLICK listeners - my rollovers work fine, using TweenLite, but I can’t click some buttons… some buttons I can. I’ve not seen this before and it’s quite frustrating at the moment.