Subscribe maillist for outlook

Hi i made a subscribe and unsubscribe feature for a site.
It saves email adresses and gives it a ID.
I want to send newsletters to the people that subscribe them selves, but i always want it to be send to the most updated version from the database.
Is it possible to send a email from outlook and connect it to a database list ?
Or is there a other way to send emails and and send it to the list from my database ?

Please let me know, any help is welcome.

Regards,
Vectar