Best way?

I want to make a portfolio site in a kind of anime style sort of like the zelda site? what software would be best to use??

I was thinking about doing it all in flash and then just doing it that way then I started playing with FIREWORKs but then I wanted to use 3DS Max with swift3D?

could some one give me some advice I want it to have the cartoon style whhich way would be the easiest/most practical?

many thanks