Button Hit/Target area on HTML

May be a daft question, but does HTML (or anything for that matter) allow you to define a hit area for buttons by giving x/y values and a size or something?

I’ve made a design in photoshop i want to use as a background to php and html pages but i need to make parts of it buttons to hyperlink to different pages.

Direction to info would be great.
Cheers :sigh: