Cd Rom creation bits and bobs

Just about to make my first cd rom for someone other that me and I need some hints from people with experience. (Gonna make it in Flash and publish an exe)

Screen size… shall I make it in 800x600 and then fscommand it to full screen? is that a good idea?

Autorun… I’m ok with that, but what about macs? Will it work?

Loading… If it turns out to be a big file size, will it need a preloader or not? I’ve searched around and there seems to be mixed views.

Anything else I should think about? Any single answers or random bits of information would be great and rewarded with lollies.

Cheers.