Dreamweaver acting up

Has anyone else ever had this problem?
When you design a website in Dreamweaver, it all looks cool.
When it comes to testing- thats a whole different story.
The layers go mad, all over the shop.
So you fix that, and yeah, it looks messed up in dw, but thats ok, you can live with that.
Then it comes to publishing-
It’s messed up YET AGAIN!

Am I the only one?

Cheers.

(my birthday saturday!)