How can i create something like this?

how can i create something like this and is Flash suited or is Fireworks MX better suited. I want to create a site based on the one i send in the picture. Help is much apreciated, other forums are not that responsive on the matter.

wot i need is: Size (in pixels) to get a nice view in maximized windows, how to create the layout, getting to stick the “menus” out a little.

Thanks all.

Dude