How to lay my page out properly? Graphic grids?

Hi,

Ive been designing websites for a while now, Mainly using html and css for layout. Ive just got in to flash and now find it quite hard to lay my pages out so they look clean and professional-you know what i mean.

Im not a qualified graphic designer but have heard about graphic grids and their use in setting pages out. One book ive found on amazon in particular-

Grid Systems in Graphic Design
by Josef Muller-Brockmann , Josef Muller

**-**is highly recommended but im wondering if its applicable to web design.

Could anyone tell me how they go about setting a page out so it looks right**.**
Do you use the graphic grid or just play until you get it right???