Flash Hybrid Site Question: How much CSS?

Can a layout like this: http://relevantmagazine.com

(with flash content throughout different sections)

come close to being laid out in CSS or are the tables necessary?

I’ve done some simpler css layouts but I’d just like to know, it it even worth trying to layout without tables?

I have a site that has a lot less content but will be hybrid with three columns and various size content boxes in each column with flash content in some of them.

Any example sites that accomplish something this complex with CSS?

Thanks for the input,