HTML Email?

What is the best way to setup an HTML email that I want to send out to 100’s of people?? It needs to work on both mac/pc and be compatible with most email clients?? Any suggestions?? Please take into account I know very little about web programming. I am a graphic designer so designing the look of the email should be a breeze - sending it and making it work will be difficult. It will mainly be a graphic but a few of the images need to link to certain parts of a website!!